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Diabetes Mellitus type 2

Is an endocrine disorder characterized by hyperglycemia resulting from variable degrees of insulin resistance and deficiency

Chronic hyperglycemia of Diabetes can lead to multiorgan damage resulting in renal, neurologic, cardiovascular, and other serious complications

Also called

Diabetes Mellitus type II
Type 2 Diabetes
Type II Diabetes
Non-insulin-dependent Diabetes Mellitus
Adult-onset Diabetes

Likely risk factors

Prediabetes
Obesity
Metabolic Syndrome
Polycystic Ovary Syndrome
Gestational Diabetes Mellitus

Modifiable lifestyle factors

Poor diet, increased processed meat consumption, sweetened beverage consumption, high dietary glycemic index, low cereal fiber intake,lack of exercise, sedentary behaviors,smoking

Pathogenesis

Pathogenesis unclear, but multiple genetic lifestyle, environmental, metabolic and other risk factors suggest multifactorial process

Symptoms

Often asymptomatic and detected by screening
Symptoms and presentation of significant hyperglycemia may include:
- Polyuria
- Polydipsia
- Polyphagia
- Blurred vision
- Hyperosmolar hyperglycemic state

Symptoms associated with chronic hyperglycemia may include

Peripheral neuropathy
Frequent infections
Visual impairment
Sexual dysfunction
Bowel or bladder dysfunction
Kidney dysfunction
Cardiovascular dysfunction

Family history

Ask about family history of Diabetes

General physical examination

Assess height, weight, and body mass index
Overweight or obesity (BMI ≥ 25 kg/m2) common in adults with type 2 Diabetes
Hypertension common

Testing overview

Diagnose Diabetes with blood tests confirming

Treatment overview

Metabolic treatment targets should be individualized, generally recommended targets in adults with Diabetes include:

Lifestyle interventions include

Dietary management, including individualized medical nutrition therapy
Physical activity for ≥ 150 minutes/week
Diabetes self-management education

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