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Diabetes Mellitus type 2

Is an endocrine disorder characterized by hyperglycemia resulting from variable degrees of insulin resistance and deficiency

Chronic hyperglycemia of Diabetes can lead to multiorgan damage resulting in renal, neurologic, cardiovascular, and other serious complications

Also called

  • Diabetes Mellitus type II
  • Type 2 Diabetes
  • Type II Diabetes
  • Non-insulin-dependent Diabetes Mellitus
  • Adult-onset Diabetes 

Likely risk factors

  • Prediabetes
  • Obesity
  • Metabolic Syndrome
  • Polycystic Ovary Syndrome
  • Gestational Diabetes Mellitus

Modifiable lifestyle factors

Poor diet, increased processed meat consumption, sweetened beverage consumption, high dietary glycemic index, low cereal fiber intake,lack of exercise, sedentary behaviors,smoking

Pathogenesis

Pathogenesis unclear, but multiple genetic lifestyle, environmental, metabolic and other risk factors suggest multifactorial process

Symptoms

  • Often asymptomatic and detected by screening
  • Symptoms and presentation of significant hyperglycemia may include:
    • Polyuria
    • Polydipsia
    • Polyphagia
    • Blurred vision
    • Hyperosmolar hyperglycemic state

Symptoms associated with chronic hyperglycemia may include

  • Peripheral neuropathy
  • Frequent infections
  • Visual impairment
  • Sexual dysfunction
  • Bowel or bladder dysfunction
  • Kidney dysfunction
  • Cardiovascular dysfunction

Family history

Ask about family history of Diabetes

General physical examination

  • Assess height, weight, and body mass index
  • Overweight or obesity (BMI ≥ 25 kg/m2) common in adults with type 2 Diabetes
  • Hypertension common

Testing overview

Diagnose Diabetes with blood tests confirming

Treatment overview

Metabolic treatment targets should be individualized, generally recommended targets in adults with Diabetes include:

Lifestyle interventions include

  • Dietary management, including individualized medical nutrition therapy
  • Physical activity for ≥ 150 minutes/week
  • Diabetes self-management education

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